Chemical modification of antibiotic streptonigrin; synthesis and properties of 2'-decarboxy-2'-aminostreptonigrin (streptonigrone-2'-imine).

The structure of streptonigrone, and a comment on the biosynthesis of the streptonigrin antibiotics.

Amides of antibiotic streptonigrin and amino dicarboxylic acids or aminosugars. Synthesis and biological evaluation.

Streptonigrin has been shown to be a potent cytotoxic agent, with broad spectrum activity in a number of murine tumor models1\ Recently it was shown that streptonigrin is a nonintercalative antibiotic, which induces mammaliantopoisomerase II dependent DNAcleavage2). It is a strong inhibitor of the reverse transcriptase associated with avian myeloblastosis virus and humanimmunodeficiency virus3)...

Modification Conductivity of Emeraldine Base form of Polyaniline-Cobalt Sulphate Nanocomposite Synthesis by Chemical Method

The structural and electrical properties of polyaniline-cobalt sulphate nanocomposite prepared by chemical method.Polyaniline-cobalt sulphate nanocomposites were synthesized by the cobalt sulphate and ammonium persulphate and aniline.This paper reports on chemical technique using for synthesis of cobalt nanoparticles in the composite bridge is aniline. Electrical conductivity of polyaniline wit...

Modification Conductivity of Emeraldine Base form of Polyaniline-Cobalt Sulphate Nanocomposite Synthesis by Chemical Method

The structural and electrical properties of polyaniline-cobalt sulphate nanocomposite prepared by chemical method.Polyaniline-cobalt sulphate nanocomposites were synthesized by the cobalt sulphate and ammonium persulphate and aniline.This paper reports on chemical technique using for synthesis of cobalt nanoparticles in the composite bridge is aniline. Electrical conductivity of polyaniline wit...

Kinetic analysis of inhibition of reverse transcriptase by streptonigrin.

The antitumor antibiotic, streptonigrin (1), was first isolated from Streptomyces flocculus1^. Later, the inhibition of avian myeloblastosis virus (AMV) reverse transcriptase by 1 was reported by Chirigos et al.2\ while no inhibition was observed with methyl streptonigrin (2), suggesting the importance of the carboxyl group for this activity. To confirm this aspect, the biological properties of...